Article date: August 1961
By: P. N. AARSEN, J. NOORDWIJK in Volume 17, Issue 1, pages 41-50
Histamine‐induced acid gastric secretion in the anaesthetized rat was not diminished by poldine in a dose which reduced vagally stimulated gastric contractions by approximately 75%. A dose of atropine, twice as large as the dose which reduced gastric contractions by 75%, had no apparent effect on the histamine‐stimulated acid gastric secretion up to 2 hr after the injection. Only when more than 40 times as much atropine was injected did a slight inhibition of the acid secretion occur in 80 to 120 min. Propantheline, in a dose which inhibited gastric contractions by approximately 75%, slightly diminished acid secretion in 40 to 80 min. This effect was not increased by a further dose of propantheline. It was concluded that, in so far as any inhibition of acid gastric secretion had occurred, this could not be interpreted as an anti‐muscarine or a direct toxic effect, but rather as an indirect effect possibly due to interference with the blood flow through the stomach wall.
DOI: 10.1111/j.1476-5381.1961.tb01102.x
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