Article date: August 1961
By: P. S. J. SPENCER, G. B. WEST in Volume 17, Issue 1, pages 137-143
Injections of thyroxine sodium increased the sensitivity of mice to histamine, the maximal effect occurring after 6 days. The sensitivity to 5‐hydroxytryptamine was increased to a lesser extent. Hydrocortisone antagonized this effect of thyroxine, whereas anti‐thyroid drugs alone decreased the sensitivity to histamine. Treatment with thyroxine also raised the metabolic rate, the peak again being reached after 6 days. As treatment was continued beyond 6 days, the adrenal gland enlarged and its secretion probably accounted for the decline in the histamine sensitivity.
DOI: 10.1111/j.1476-5381.1961.tb01114.x
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