Article date: April 1961
By: B. LILJA, S.‐E. LINDELL in Volume 16, Issue 2, pages 203-208
The metabolism of injected [14C]‐histamine was studied in heart‐lung‐liver preparations and heart‐lung preparations from cats. When the liver was included in the circulation the injected histamine was rapidly eliminated from the blood, some of its metabolites appearing in the blood within 2 min after the injection. More than 70% of the injected histamine was metabolized to 1‐methylimidazol‐4‐ylacetic acid. In the heart‐lung preparations [14C]‐histamine disappeared much more slowly from the blood and the major metabolite was 4‐(2‐aminoethyl)‐1‐methylimidazole (methylhistamine). Less than 4% of the injected 14C was recovered in the form of imidazol‐4(or 5)‐ylacetic acid. In none of the experiments was there any measurable formation of acetylhistamine.
DOI: 10.1111/j.1476-5381.1961.tb00314.x
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