THE EXCRETION OF SODIUM 6‐(2,6‐DIMETHOXYBENZ‐AMIDOPENICILLANATE) MONOHYDRATE IN RATS

Article date: December 1960

By: PATRICIA M. HARRISON, JEAN A. WHITE, G. T. STEWART in Volume 15, Issue 4, pages 571-573

The excretion of sodium 6‐(2: 6 dimethoxybenzamido) penicillanate monohydrate has been studied. When injected intramuscularly it was rapidly excreted in the bile and urine of rats, but only in trace amounts in the faeces. The excretion products in the bile (2 to 3% of the dose) and urine (26–84% of the dose) are microbiologically active. The product in the bile may be in conjugated form.

DOI: 10.1111/j.1476-5381.1960.tb00284.x

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