SOME ACTIONS OF SUBSTITUTED CHOLINE PHENYL ETHERS, PARTICULARLY OF CHOLINE 2:6‐XYLYL ETHER

Marked nicotine‐like stimulant properties are possessed by choline phenyl ether and choline o‐tolyl ether, and to a decreasing extent by choline 2:6‐xylyl ether and choline 2:4:6‐mesityl ether. The compounds all show neuromuscular blocking properties, which are of short duration and pass from mainly decamethonium‐like to mainly curare‐like as more methyl groups are added to the phenyl nucleus. This series of compounds also possesses muscarinic, weak anti‐adrenaline and vasodilator properties, as well as long‐lasting local anaesthetic effects in the two compounds tested by intradermal injection.

DOI: 10.1111/j.1476-5381.1957.tb00140.x

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