Article date: April 2015
By: Janna K. Duong, Shaun S. Kumar, Timothy J. Furlong, Carl M. Kirkpatrick, Garry G. Graham, Jerry R. Greenfield, Ken M. Williams, Richard O. Day, in Volume 79, Issue 4, pages 617-623
Aims
To compare the pharmacokinetics of metformin between diabetic Indigenous (Aboriginal and Torres Strait Islander) and non‐Indigenous patients.
Methods
An observational, cross‐sectional study was conducted on type 2 diabetic Indigenous and non‐Indigenous patients treated with metformin. Blood samples were collected to determine metformin, lactate, creatinine and vitamin B12 concentrations and glycosylated haemoglobin levels. A population model was used to determine the pharmacokinetic parameters.
Results
The Indigenous patients (median age 55 years) were younger than the non‐Indigenous patients (65 years), with a difference of 10 years (95% confidence interval 6–14 years, P < 0.001). The median glycosylated haemoglobin was higher in the Indigenous patients (8.5%) than in the non‐Indigenous patients (7.2%), with a difference of 1.4% (0.8–2.2%, P < 0.001). Indigenous patients had a higher creatinine clearance (4.3 l h−1) than the non‐Indigenous patients (4.0 l h−1), with a median difference of 0.3 l h−1 (0.07–1.17 l h−1; P < 0.05). The ratio of the apparent clearance of metformin to the creatinine clearance in Indigenous patients (13.1, 10.2–15.2; median, interquartile range) was comparable to that in non‐Indigenous patients (12.6, 9.9–14.9). Median lactate concentrations were also similar [1.55 (1.20–1.88) vs. 1.60 (1.35–2.10) mmol l−1] for Indigenous and non‐Indigenous patients, respectively. The median vitamin B12 was 306 pmol l−1 (range 105–920 pmol l−1) for the Indigenous patients.
Conclusions
There were no significant differences in the pharmacokinetics of metformin or plasma concentrations of lactate between Indigenous and non‐Indigenous patients with type 2 diabetes mellitus. Further studies are required in Indigenous patients with creatinine clearance <30 ml min−1.
DOI: 10.1111/bcp.12525
View this article