Antifungal agents and therapy for infants and children with invasive fungal infections: a pharmacological perspective

Article date: June 2013

By: Jodi M. Lestner, P. Brian Smith, Michael Cohen‐Wolkowiez, Daniel K. Benjamin, William W. Hope, in Volume 75, Issue 6, pages 1381-1395

Invasive fungal infections, although relatively rare, are life‐threatening diseases in premature infants and immunocompromised children. While many advances have been made in antifungal therapeutics in the last two decades, knowledge of the pharmacokinetics and pharmacodynamics of antifungal agents for infants and children remains incomplete. This review summarizes the pharmacology and clinical utility of currently available antifungal agents and discusses the opportunities and challenges for future research.

DOI: 10.1111/bcp.12025

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