Article date: January 2012
By: Seung Young Kim, Sung Woo Jung, Jeong Han Kim, Ja Seol Koo, Hyung Joon Yim, Jong Jae Park, Hoon Jai Chun, Sang Woo Lee, Jai Hyun Choi, in Volume 73, Issue 1, pages 140-143
WHAT IS ALREADY KNOWN ABOUT THIS SUBJECT
AIM
We compared three times daily dual therapy with standard triple therapy for effectiveness and safety in H. pylori infection.
METHODS
Two hundred and four H. pylori positive patients with peptic ulcer were randomly assigned to one of two regimens: (i) triple therapy with amoxicillin, clarithromycin and lansoprazole twice daily for 2 weeks or (ii) dual therapy with amoxicillin and lansoprazole three times daily for 2 weeks. The success of eradication was evaluated 4 to 5 weeks after completing treatment.
RESULTS
The eradication rate was 82.8% in the triple therapy group and 78.4% in the dual therapy group by per protocol analysis. This difference was not significant (P= 0.573). Adverse events were more frequent in the triple therapy group than in the dual therapy group (P= 0.002).
CONCLUSIONS
Because dual therapy had fewer side effects than triple therapy and a similar eradication rate, dual therapy may provide an acceptable alternative first line therapy for H. pylori eradication in Korea.
DOI: 10.1111/j.1365-2125.2011.04048.x
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