Article date: June 1979
By: C Devaux, P Schoepffler, JP Gauthier‐Lafaye, in Volume 7, Issue S3, pages 323S-326S
1 Mixed agonist‐antagonist analgesics have analgesic action but also possess a range of side‐effects. 2 Narcotic antagonists do not reverse the non‐specific effects of opiates. 3 Under certain circumstances the effects of agonists and mixed agonist‐antagonists can be additive. 4 Chronic dosage of mixed agonist‐antagonists leads to a lower level of dependence than that observed with the standard narcotics. 5 Mixed agonist‐antagonists may not antagonize the respiratory effects of narcotics and may result in potentiation of such depression.
DOI: 10.1111/j.1365-2125.1979.tb04708.x
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