Article date: February 2008
By: Suman Lal, Edwin Sandanaraj, Srinivasa Rao Jada, Ming‐Chai Kong, Lai‐Heng Lee, Boon‐Cher Goh, Soo‐Chin Lee, Balram Chowbay, in Volume 65, Issue 2, pages 260-264
What is already known about this subject
Aims
To investigate the influence of APOE genotypes and VKORC1 haplotypes on warfarin dose requirements in Asian patients.
Methods
A total of 174 Asian patients (Chinese, n = 96; Malays, n = 50; Indians, n = 28) who had stable daily warfarin doses for at least 1 month were recruited. Following genomic DNA extraction from venous blood, pharmacogenetic analysis of APOE and VKORC1 genes was done by DNA sequencing.
Results
The majority of the Asian patients (78%) harboured the APOE ε3/ε3 genotype. Different APOE genotypes were found not to have any significant influence on mean daily warfarin dose requirements. Warfarin dose requirements in the pooled Asian patients homozygous for the VKORC1 H1 haplotype were significantly lower compared with patients homozygous for the H7 haplotype (H1‐H1 vs. H7‐H7: 2.79 ± 1.06 mg day−1vs. 5.45 ± 2.3 mg day−1, P < 0.001).
Conclusions
The present study suggests that APOE variants have minimal impact on warfarin dose requirements in Asian patients, probably due to the low frequency of ε4 allele containing genotypes.
DOI: 10.1111/j.1365-2125.2007.03053.x
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