Article date: October 2007
By: Fergal Donnellan, Garret Cullen, John E. Hegarty, P. Aiden McCormick, in Volume 64, Issue 4, pages 550-552
Aim To report three cases of extensive skin necrosis in cirrhotic patients treated with the vasoconstrictor agent terlipressin (Glypressin).
Methods We identified three patients who developed skin necrosis and determined any factors, which put them at an increased risk of doing so.
Results Two patients were obese and developed extensive abdominal wall skin necrosis. The third patient had lower limb chronic venous insufficency and developed extensive necrosis of both lower limbs.
Conclusions With increasing clinical use of terlipressin and an increasing incidence of obesity and non‐alcoholic fatty liver disease‐related cirrhosis, the incidence of these serious complications is likely to rise. Earlier recognition and treatment may lead to improved outcome.
DOI: 10.1111/j.1365-2125.2007.02921.x
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