Article date: March 2007
By: Ciro Costagliola, Claudio Campa, Francesco Parmeggiani, Carlo Incorvaia, Paolo Perri, Sergio D’Angelo, Giuseppe Lamberti, Adolfo Sebastiani, in Volume 63, Issue 3, pages 376-379
Aim
To investigate whether dorzolamide modifies peripapillary retinal haemodynamics in juvenile primary open‐angle glaucoma (JPOAG) patients treated with timolol.
Methods
In 40 JPOAG subjects, before and after dorzolamide coadministration with timolol, the following examinations were achieved: intraocular pressure (IOP), blood pressure (BP), ocular perfusion pressure (OPP), heart rate (HR), visual field and retinal flowmetry.
Results
Adjunctive therapy with dorzolamide induced the following modifications: IOP reduction [1.75 mmHg, 95% confidence interval (CI) 1.23, 2.26; P < 0.05], OPP increase (5.09 mmHg, 95% CI 2.97, 7.20; P < 0.02) and retinal blood flow improvement (35.0 arbitrary units, 95% CI 12.20, 57.80; P < 0.03). BP, HR and visual field indices did not change.
Conclusions
Dorzolamide, in association or in fixed combination with timolol, significantly improves retinal blood flow in JPOAG patients.
DOI: 10.1111/j.1365-2125.2006.02768.x
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