Article date: January 2006
By: Sharon J. Gardiner, Matthew P. Doogue, Mei Zhang, Evan J. Begg, in Volume 61, Issue 1, pages 101-104
Aims
To determine the milk‐to‐plasma (M/P) concentration ratio of celecoxib, and estimate likely infant exposure.
Methods
Blood and milk were sampled for 48 h after oral administration of celecoxib 200 mg to six lactating volunteers. The M/P ratio was derived from the area under the concentration–time curves (0–∞) and the infant ‘dose’ estimated from celecoxib concentrations in milk.
Results
The median (range) M/P ratio was 0.18 (0.15–0.26). The median (range) infant ‘dose’ was 0.23% (0.17–0.30%) of the maternal dose, adjusted for weight.
Conclusion
The relative ‘dose’ of celecoxib to which infants are exposed via milk is very low, suggesting that breastfeeding during routine dosing would pose minimal risk.
DOI: 10.1111/j.1365-2125.2005.02520.x
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