Article date: November 2002
By: Anna Nordmark, Stefan Lundgren, Birgitta Ask, Fredrik Granath, Anders Rane, in Volume 54, Issue 5, pages 504-510
Aims To investigate the influence of the CYP1A2*1F mutation on CYP1A2 activity in smoking and nonsmoking pregnant women.
Methods
Pregnant women (n = 904) who served as control subjects in a case‐control study of early fetal loss were investigated. They were phenotyped for CYP1A2 using dietary caffeine and the urinary ratio AFMU + 1X + 1 U/1,7 U. An assay for CYP1A2*1F using 5′‐nuclease assay (Taqman) was developed to genotype the population.
DOI: 10.1046/j.1365-2125.2002.01673.x
View this article