Article date: February 1978
By: BE Leonard, in Volume 5, Issue S1, pages 11S-12S
1 Mianserin does not affect the uptake of biogenic amines into rat brain, in contrast to tricyclic antidepressants which block amine uptake. 2 Mianserin increases the turnover of noradrenaline (NA) in rat brain after acute or chronic administration, whereas tricyclic antidepressants reduce turnover of NA and 5‐hydroxytryptamine. 3 It should not be assumed that a compound must inhibit amine re‐uptake mechanisms before it can be considered as a potential antidepressant.
DOI: 10.1111/j.1365-2125.1978.tb04568.x
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