Interaction between the LMWH reviparin and aspirin in healthy volunteers

AimsTo investigate potential interactions between reviparin and acetylsalicylic acid (ASA 300 mg o.d. from day 1–5).

MethodsIn an open, randomized, three‐way‐cross over study nine healthy volunteers received reviparin (s.c. injection of 6300 anti‐Xa units) or placebo from days 3 to 5 and acetylsalicylic acid (ASA 300 mg) or placebo from days 1 to 5. Assessments included bleeding time (BT), collagen (1 µg ml⁻¹) induced platelet aggregation (CAG), heptest, plasma antifactor Xa‐activity and activated partial thromboplastin time (aPTT).

ResultsMedian bleeding time at day 5 was 5.5 min after reverparin alone and after ASA alone and was 9.6 min after the combination of reviparin and ASA. ASA treatment reduced CAG from 84% to 40 to 50% of A_max; values after combined treatment of reviparin with ASA were not different from those after ASA alone. aPTT was prolonged to 32 s after reviparin; this effect was not modified if subjects received ASA. Combined treatment with ASA and reviparin had no effect on plasma anti‐Xa‐activity and heptest compared with reviparin alone.

ConclusionsWe could not entirely exclude a small interaction between reviparin and ASA on bleeding time, but the effect is probably without clinical significance.

DOI: 10.1046/j.1365-2125.2000.00173.x

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