Article date: September 1998
By: Marian Wald Myers, Hershel Jick, in Volume 46, Issue 3, pages 251-253
Aims To estimate the risk of idiopathic acute liver disease among users of terfenadine.
Methods We conducted a population‐based cohort study based on the General Practice Research Database (GPRD) in the U.K. All persons who received at least one prescription for terfenadine during the period 1991 through 1995 were eligible for the study. Among these patients we identified all those with a diagnosis of a liver disorder requiring hospitalization or referral to a consultant within 60 days of a prior prescription for terfenadine. We obtained clinical records, including hospital discharge summaries, consultant reports and relevant laboratory results in order to identify a potentially drug‐inducible liver illness.
Results From a cohort of 210 683 recipients of terfenadine, we found only three cases of acute liver disease where a causal connection to terfenadine could not be ruled out, yielding a risk estimate of 1.4/100 000 users (95% CI 0.5, 4.2) and 0.5/100 000 prescriptions (95% CI 0.2, 1.4). All cases were receiving a concomitant hepatotoxic drug and all had a full recovery.
Conclusion The use of terfenadine is rarely associated with idiopathic acute liver disease.
DOI: 10.1046/j.1365-2125.1998.00772.x
View this article