Article date: April 1997
By: Marian Wald Myers, Hershel Jick, in Volume 43, Issue 4, pages 446-448
Aims The objective of this study was to quantify the risk of serious blood and skin disorders associated with co‐trimoxazole.
Methods We conducted a population‐based cohort study of serious blood and skin disorders requiring hospitalization among otherwise healthy users of co‐trimoxazole at Group Health Cooperative and Puget Sound (GHC).
Results During the years 1987 to 1993 we found six cases of co‐trimoxazole‐associated blood disorders and three cases of co‐trimoxazole‐associated skin disorders yielding risks of 5.6/100 000 (95% CI 2.6–12.2) and 2.8/100 000 (95% CI 0.9–8.2) respectively. In all cases found there was prompt recovery after discontinuation of co‐trimoxazole. We found no cases of toxic epidermal necrolysis.
Conclusions We conclude that the risk of blood and skin disorders associated with the use of co‐trimoxazole leading to hospitalization is low.
DOI: 10.1046/j.1365-2125.1997.00584.x
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