Article date: November 1996
By: TERRY E. JONES, RAYMOND G. MORRIS, in Volume 42, Issue 5, pages 642-644
The pharmacokinetic interaction between the calcium channel blocking drug, diltiazem (DTZ), the antifungal agent itraconazole (ICZ) and the immunosuppressive drug cyclosporin (CsA) was studied in a patient with a single lung transplant. The CsA area under curve estimations demonstrated a significant increase when ICZ was co‐prescribed (5836 μg l‐1 h vs 8159 μg l‐1 h) but no increase when DTZ was co‐prescribed with CsA (5836 μg l‐1 h vs 5069 μg l‐1 h). Despite widespread use as a CsA‐sparing agent, DTZ does not always increase CsA concentrations.
DOI: 10.1111/j.1365-2125.1996.tb00123.x
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