A simple gas chromatographic method for the determination of nomifensine in plasma and a comparison of the method with other available techniques.

Article date: April 1977

By: J. Chamberlain, HM Hill, in Volume 4, Issue S2, pages 117S-121S

1. A rapid simple gas chromatographic technique for determining nomifensine in plasma is described. 2. Nomifensine is rapidly absorbed after oral administration to man. 3. Following a 100‐mg dose, peak levels of an acid‐labile conjugate of 2–3 microgram/ml are reached about 1.5 h after administration. 4. The conjugate is cleared with a half‐life of between 1 and 2 hours.

DOI: 10.1111/j.1365-2125.1977.tb05737.x

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