Article date: December 1993
By: GIAN MARIA PACIFICI, GIOVANNA MARCHI, in Volume 36, Issue 6, pages 593-597
Phenol‐ and catechol‐ sulphotransferase activities were measured with p‐nitrophenol and dopamine as substrates in platelets obtained from 100 newborns and 100 healthy adults.
Mean ± (s.d.) estimates of catechol sulphotransferase activity were 7.07 ± 5.93 (adult) and 13.3 ± 6.42 (newborn) pmol min−1 mg−1 protein, respectively (P < 0.001). The coefficients of variation were 84% (adult) and 48% (newborn). The frequency distribution of sulphotransferase activity was symmetric and did not deviate significantly from normality in newborn platelets, but was positively skewed in adult platelets.
Mean ± (s.d.) estimates of phenol sulphotransferase activity were 3.01 ± 3.21 (adult) and 4.80 ± 4.34 (newborn) pmol min−1 mg−1, respectively (P < 0.001). The coefficients of variation were 107% (adult) and 90% (newborn). The frequency distribution of sulphotransferase activity was positively skewed in both newborn and adult platelets.
Since sulphotransferase activity in platelets is well‐expressed at birth and a prenatal development of sulphotransferase has been described in mid‐gestational human foetal liver, the newborn should be able to sulphate drugs.
Phenol‐ and catechol‐ sulphotransferase activities were measured with p‐nitrophenol and dopamine as substrates in platelets obtained from 100 newborns and 100 healthy adults.
Mean ± (s.d.) estimates of catechol sulphotransferase activity were 7.07 ± 5.93 (adult) and 13.3 ± 6.42 (newborn) pmol min−1 mg−1 protein, respectively (P < 0.001). The coefficients of variation were 84% (adult) and 48% (newborn). The frequency distribution of sulphotransferase activity was symmetric and did not deviate significantly from normality in newborn platelets, but was positively skewed in adult platelets.
Mean ± (s.d.) estimates of phenol sulphotransferase activity were 3.01 ± 3.21 (adult) and 4.80 ± 4.34 (newborn) pmol min−1 mg−1, respectively (P < 0.001). The coefficients of variation were 107% (adult) and 90% (newborn). The frequency distribution of sulphotransferase activity was positively skewed in both newborn and adult platelets.
Since sulphotransferase activity in platelets is well‐expressed at birth and a prenatal development of sulphotransferase has been described in mid‐gestational human foetal liver, the newborn should be able to sulphate drugs.
DOI: 10.1111/j.1365-2125.1993.tb00420.x
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