Article date: July 1992
By: F Pisani, A Fazio, C Artesi, G Oteri, E Spina, T Tomson, E Perucca, in Volume 34, Issue 1, pages 85-87
The effect of the valpromide isomer valnoctamide (VCD, 200 mg three times daily for 8 days), an over‐the‐counter tranquillizer, on the elimination kinetics of a single oral dose of carbamazepine‐10, 11‐ epoxide (CBZ‐E, 100 mg) was investigated in healthy subjects. During VCD treatment, the half‐life of CBZ‐E was prolonged significantly compared with control (19.7 +/‐ 6.7 h vs 6.9 +/‐ 2.0 h, means +/‐ s.d., P less than 0.01), and its oral clearance decreased four‐fold (from 109.6 +/‐ 30.7 to 28.8 +/‐ 11.1 ml h‐1 kg‐1, P less than 0.01). These findings indicate that VCM, like valpromide, strongly inhibits epoxide hydrolase in vivo.
DOI: 10.1111/j.1365-2125.1992.tb04114.x
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