Article date: July 1992
By: J Drewe, R Meier, J Vonderscher, D Kiss, U Posanski, T Kissel, K Gyr, in Volume 34, Issue 1, pages 60-64
1. The oral absorption of cyclosporin from three new semi‐solid oral formulations was compared with the standard soft gelatine preparation in twelve healthy male volunteers. One formulation was based on a solid micellar solution, while the other two, with different in vitro release properties, were based on a microemulsion principle. 2. The results showed that the solid micellar solution and the faster releasing microemulsion formulation increased the extent of absorption on average by 45.2 and 49.0%, respectively, compared with the reference soft gelatine capsule.
DOI: 10.1111/j.1365-2125.1992.tb04108.x
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