Article date: November 1991
By: MJ Iredale, CM Dixon, PW Ind, in Volume 32, Issue 5, pages 637-638
The effect of salbutamol on bronchoconstriction induced by inhaled sodium metabisulphite has been studied in 12 atopic subjects. Salbutamol (200 micrograms, 3.5 x 10(‐7) M) and matched placebo were administered by identical metered dose inhaler 15 min before a dose‐ response to sodium metabisulphite (1.25‐100 mg ml‐1) was performed. Geometric mean provocative dose of metabisulphite causing a 35% fall in sGaw after placebo pretreatment was 12.8 [5.75‐28.1, 95% Cl] mumol, and after salbutamol was 75.9 [46.5‐126] mumol. Mean maximum fall in sGaw after placebo pre‐treatment was 47.4 [41‐53.9]%. At the same metabisulphite concentration mean maximum fall in sGaw after salbutamol was 2.9 [‐8.2‐14.1]%.
DOI: 10.1111/j.1365-2125.1991.tb03967.x
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