Article date: January 1991
By: MJ Morley, CM Bradshaw, E Szabadi, in Volume 31, Issue 1, pages 99-101
The effects of single doses of clonidine hydrochloride (200 micrograms), yohimbine hydrochloride (22 mg), a combination of the two treatments, and placebo, on some autonomic functions were studied in healthy volunteers using a double‐blind crossover design. Clonidine prolonged the recovery time of the light reflex, lowered systolic blood pressure and reduced subjectively rated alertness; these effects were reversed by yohimbine. Responsiveness of sweat glands to carbachol was not affected by the treatments.
DOI: 10.1111/j.1365-2125.1991.tb03864.x
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