DIGOXIN CONCENTRATIONS IN SERUM AND SALIVA: RELATIONSHIP TO ECG CHANGES AND DOSAGE IN HEALTHY VOLUNTEERS

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After 1 week of baseline observations increasing oral doses of digoxin were administered to four healthy volunteers over a 6–7 week period.

After 1 week of baseline observations increasing oral doses of digoxin were administered to four healthy volunteers over a 6–7 week period.

A dose‐response relationship exists with regards to PTQ‐changes (a quantitative measure of ECG‐changes).

PTQ‐changes were related linearly to both serum and salivary digoxin levels.

PTQ‐changes appear to be useful as a non‐invasive measure for studying various aspects of digoxin pharmacodynamics.

Serial salivary digoxin levels might be a better index of the effect of cardiac glycosides than individual or serial serum levels.

DOI: 10.1111/j.1365-2125.1976.tb00357.x

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