Article date: August 1976
By: HEATHER ASHTON, J. E. MILLMAN, ROSEMARY TELFORD, J. W. THOMPSON, T. F. DAVIES, R. HALL, in Volume 3, Issue 4, pages 523-531
Three hypothalamic regulatory hormones, thyrotrophin‐releasing hormone (TRH), luteinizing hormone/follicle‐stimulating hormone‐releasing hormone (LH/FSH—RH) and growth hormone‐release inhibiting hormone (GH—RIH) given intravenously had no effect on the electroencephalographic response known as the contingent negative variation (CNV) in normal subjects.
TRH was given as a 10 ml infusion of 600 μg over 8 min to six subjects. This produced subjective sensations and a rise in heart rate but no significant alteration of CNV magnitude.
LH/FSH—RH was given in a dose of 200 μg in 10 ml over 2 min to six subjects. This had no effect on CNV magnitude or heart rate and produced no subjective effects.
GH—RIH was given as a 10 ml infusion of 250 μg over 10 min to six subjects. Again there was no alteration in the magnitude of the CNV; the heart rate was slowed.
Three hypothalamic regulatory hormones, thyrotrophin‐releasing hormone (TRH), luteinizing hormone/follicle‐stimulating hormone‐releasing hormone (LH/FSH—RH) and growth hormone‐release inhibiting hormone (GH—RIH) given intravenously had no effect on the electroencephalographic response known as the contingent negative variation (CNV) in normal subjects.
TRH was given as a 10 ml infusion of 600 μg over 8 min to six subjects. This produced subjective sensations and a rise in heart rate but no significant alteration of CNV magnitude.
LH/FSH—RH was given in a dose of 200 μg in 10 ml over 2 min to six subjects. This had no effect on CNV magnitude or heart rate and produced no subjective effects.
GH—RIH was given as a 10 ml infusion of 250 μg over 10 min to six subjects. Again there was no alteration in the magnitude of the CNV; the heart rate was slowed.
DOI: 10.1111/j.1365-2125.1976.tb04871.x
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