Article date: November 1989
By: MJ Ward, DC Buss, J Ellershaw, A Nash, PA Routledge, in Volume 28, Issue 5, pages 616-618
After intranasal administration of metoclopramide, (5 mg in 0.5 ml sterile water) the maximum plasma concentration of 13.5 +/‐ 7.3 (mean +/‐ s.d.) ng ml‐1 was achieved. Absolute bioavailability was 50.5 +/‐ 29.5%, 110 +/‐ 41 min later. We conclude that the intranasal route does not allow rapid absorption of the drug and is not associated with greater bioavailability than the oral route.
DOI: 10.1111/j.1365-2125.1989.tb03552.x
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