Variable metabolism of pinacidil: lack of correlation with the debrisoquine and trimethylamine C‐ and N‐oxidative polymorphisms.

1. The urinary excretion of pinacidil and its N‐oxide in man was found to vary over a five‐fold range. 2. Studies in individuals with inherited deficiencies for C‐hydroxylation (debrisoquine type) and trimethylamine N‐oxidation showed that the N‐oxidation of pinacidil did not co‐segregate with these oxidative polymorphisms. 3. It is concluded that the variable N‐oxidation of pinacidil is most likely to be due to variations in the activity of the P‐450 isozymes rather than in the microsomal flavoprotein containing mixed‐function amine oxidase of Ziegler which is considered to be responsible for the N‐oxidation of trimethylamine.

DOI: 10.1111/j.1365-2125.1989.tb05389.x

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