Article date: December 1988
By: LA Cerasa, JS Bertino, EA Ludwig, M. Savliwala, E. Middleton, RL Slaughter, in Volume 26, Issue 6, pages 800-802
The effects of 3 days of pretreatment with cardioselective doses of atenolol on theophylline pharmacokinetics were determined. Nine healthy nonsmoking male volunteers received 6 mg kg‐1 i.v. aminophylline under baseline conditions and after both 50 mg day‐1 and 100 mg day‐1 atenolol. Theophylline clearance, volume of distribution and half‐life were not influenced by atenolol pretreatment. These data indicate that cardioselective doses of atenolol do not alter the pharmacokinetics of theophylline.
DOI: 10.1111/j.1365-2125.1988.tb05323.x
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