Article date: November 1988
By: PT Reeves, P. Hanrahan, J. Edelman, KF Ilett, in Volume 26, Issue 5, pages 563-568
1. The disposition of sulphadimidine (15 mg kg‐1 orally) was investigated in six chronic osteoarthritis patients (four slow and two fast acetylators) prior to and 4 days following intra‐articular administration of glucocorticoids. 2. The mean (+/‐ s.e. mean) renal clearance of sulphadimidine was increased from 0.03 +/‐ 0.01 to 0.07 +/‐ 0.02 ml min‐1 kg‐1 (P = 0.01) following the administration of intra‐ articular steroid. 3. Mean metabolic clearance and volume of distribution data were similar on the two study days. However, two of the slow acetylators showed marked increases (63% and 193%) in metabolic clearance following steroid treatment.
DOI: 10.1111/j.1365-2125.1988.tb05296.x
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