Article date: April 1988
By: AR Manara, MP Shelly, K Quinn, GR Park, in Volume 25, Issue 4, pages 518-521
The pharmacokinetics of oral controlled release morphine and metoclopramide were investigated in 20 patients in a double‐blind, randomly allocated study. The concurrent administration of metoclopramide and oral controlled release morphine led to a faster onset and increased level of sedation compared with the administration of oral controlled release morphine alone. Whilst the increased sedation may be advantageous in anaesthetic practice, it may be a potential problem in patients starting longer term therapy with these drugs.
DOI: 10.1111/j.1365-2125.1988.tb03338.x
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