Article date: April 1988
By: OJ Robb, J Webster, JC Petrie, JD Harry, J Young, in Volume 25, Issue 4, pages 433-438
1. The selective beta 2‐adrenoceptor antagonist ICI 118,551, 50 mg orally given thrice daily, did not lower blood pressure in hypertensive patients known to respond to therapy with atenolol or propranolol. 2. This dosage regimen resulted in a small decrease in supine heart rate which might represent partial beta 1‐adrenoceptor antagonism by ICI 118,551. 3. The results suggest that beta 2‐selective antagonism does not play a role in the hypotensive action of beta‐adrenoceptor antagonists.
DOI: 10.1111/j.1365-2125.1988.tb03326.x
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