Article date: June 1987
By: RA Robson, JO Miners, AG Whitehead, DJ Birkett, in Volume 23, Issue 6, pages 772-775
Two groups of six healthy male volunteers were studied to assess the possibility of an interaction between dextropropoxyphene and theophylline or tolbutamide using a randomised, crossover design. Subjects received theophylline 125 mg 8 hourly or tolbutamide 500 mg i.v. with and without dextropropoxyphene hydrochloride 65 mg 8 hourly. Theophylline 8‐hydroxylation was reduced by a mean of 17% but there were no changes in theophylline 1‐demethylation, theophylline 3‐ demethylation or tolbutamide hydroxylation.
DOI: 10.1111/j.1365-2125.1987.tb03115.x
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