Article date: June 1987
By: JO Atiba, G Taylor, RA Pershe, TF Blaschke, in Volume 23, Issue 6, pages 715-719
Antipyrine half‐life has been determined from measurements of antipyrine concentrations in spontaneously voided urine specimens in eleven subjects, studied on a total of forty‐seven different occasions while receiving no drugs, interferon or ketoconazole. Plasma and saliva half‐lives show good intrasubject correlation. Plasma and urine half‐ lives show good intrasubject correlation provided total urine output is at least 1.1 l day‐1. The range of intrasubject correlation coefficients for plasma and urinary half‐lives was 0.76 to 0.98, with a median value of 0.85. Saliva and urine half‐lives show good intrasubject correlation, with the range of intrasubject correlation coefficients from 0.74 to 0.98, and with a median value of 0.75. There is a small but consistent bias towards shorter urinary half‐life estimates; this averaged 0.75 h for the plasma‐urine studies and 0.192 h for the saliva‐urine studies. There were parallel changes in antipyrine half‐life estimated from plasma and urine for one of our subjects who received multiple doses of recombinant beta‐interferon and had a 150% increase in antipyrine half‐life over the study period.
DOI: 10.1111/j.1365-2125.1987.tb03106.x
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