Article date: February 1987
By: SH Jackson, MJ Jamieson, A Johnston, AM Shepherd, in Volume 23, Issue 2, pages 199-205
The rationale for the objective assessment of dose‐response curves (DRCs) is presented. Using data derived from isoprenaline/heart rate responses studies, two new statistical methods of objectively defining the terminal linear segment of an incomplete DRC are presented. Using data derived from phenylephrine/diastolic blood pressure response studies, the parallel shift quadratic model of Sumner et al. (1982) has been extended to include a measure of the suitability of the quadratic model for each individual data set using the Akaike information criterion. A parallel shift Emax model is proposed for complete DRCs.
DOI: 10.1111/j.1365-2125.1987.tb03030.x
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