Article date: January 1987
By: DT Liu, JM Savage, D Donnell, in Volume 23, Issue 1, pages 99-101
Human milk and plasma samples were obtained from five healthy nursing mothers who were taking nefopam hydrochloride (60 mg four‐hourly) for post‐episiotomy pain. Concentrations of nefopam were quantified in milk and plasma paired samples, taken daily from birth for 5 days, by a specific paired‐ion reverse phase h.p.l.c. method. Although nefopam was present in human milk in an equivalent concentration to plasma (milk: plasma ratio 1.2 +/‐ 0.7, mean +/‐ s.d.), the likely infant exposure was less than 0.05 mg kg‐1 day‐1 which, on a body weight basis, would be less than 3% of the maternal dose.
DOI: 10.1111/j.1365-2125.1987.tb03017.x
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