Article date: September 1986
By: J Caldwell, AH Staib, IA Cotgreave, M Siebert‐Weigel, in Volume 22, Issue 3, pages 351-355
Six healthy volunteers received two theophylline preparations by short intravenous infusion, at weekly intervals in a randomized cross‐over design. The solubilizer was ethylenediamine or sodium glycinate. Plasma concentrations of theophylline and ethylenediamine were measured by h.p.l.c. for up to 24 h after dosing. The pharmacokinetics of theophylline did not show any significant intra‐subject variation associated with the solubilizing agent used.
DOI: 10.1111/j.1365-2125.1986.tb02899.x
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