Excretion of trazodone in breast milk.

The excretion of breast milk was studied in six lactating women following the oral administration of a single trazodone tablet (50 mg). The milk/plasma ratio of trazodone based on area under the plasma and milk curves was small: 0.142 +/‐ 0.045 (mean +/‐ s.d.). Assuming that the babies would drink 500 ml 12 h‐1, they would be exposed to less than 0.005 mg kg‐1 as compared to 0.77 mg kg‐1 for the mothers. It is concluded that exposure of babies to trazodone via breast milk is very small.

DOI: 10.1111/j.1365-2125.1986.tb02903.x

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