Article date: September 1986
By: SG Hibberd, C Alveyn, EJ Coombes, ST Holgate, in Volume 22, Issue 3, pages 337-341
The day and night pharmacokinetics of assymetrical doses of slow release choline theophyllinate (Sabidal SR 270) were compared at day 1 and at day 4 of treatment when steady state had been achieved. Ten patients with chronic asthma were given oral choline theophyllinate 424 mg at 09.00 h and 848 mg at 21.00 h for 4 days. At regular intervals during day 1 and day 4 of treatment theophylline concentrations were measured in plasma and dried blood spots by fluorimmunoassay. Theophylline concentrations measured from dried blood spots were slightly lower than those in plasma, the difference remaining constant at all time points during day 1 and day 4 of treatment. On day 1 the mean peak plasma theophylline concentration was 5.4 +/‐ 1.0 (+/‐ s.e. mean) micrograms ml‐1 4 h after the morning dose and 11.2 +/‐ 1.6 micrograms ml‐1 4 h after the evening dose which were significantly (P less than 0.01) different. Similarly the areas under the plasma theophylline concentration‐time curves at night were significantly (P less than 0.001) greater than those observed during the day. During day 4 mean peak plasma concentrations of theophylline after the morning and larger evening dose were 13.2 +/‐ 1.3 and 12.1 +/‐ 1.4 micrograms ml‐1 respectively, which were not significantly different. No significant difference was observed between the areas under the plasma theophylline concentration‐time curves during the day and at night. However the post‐ dose time to peak was significantly delayed at night (6 h) compared to the morning (2 h, P less than 0.001).(ABSTRACT TRUNCATED AT 250 WORDS)
DOI: 10.1111/j.1365-2125.1986.tb02896.x
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