Article date: December 1984
By: RA Tokola, PJ Neuvonen, in Volume 18, Issue 6, pages 867-871
The absorption of effervescent paracetamol (1000 mg) was investigated in nine female patients during a migraine attack and in the same patients when headache free. Migraine attack decreased (P less than 0.05) the areas under the serum paracetamol concentration‐time curves (AUC) of 0‐2 h, 0‐4 h and 0‐6 h and the peak serum concentration. The severity of nausea correlated significantly with the decrease in the AUC values. Our results support findings of delayed gastric emptying in migraine attacks. Both a delay and an impairment of drug absorption may follow.
DOI: 10.1111/j.1365-2125.1984.tb02557.x
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