Article date: October 1984
By: SC Mitchell, RH Waring, CS Haley, JR Idle, RL Smith, in Volume 18, Issue 4, pages 507-521
Interindividual variation in the sulphoxidation of S‐carboxymethyl‐L‐ cysteine (750 mg p.o.) was investigated in 200 healthy volunteers. Nearly a 100‐fold difference was observed between individuals with respect to the amount of sulphoxide metabolites detected in their 0‐8 h urine (0.6 to 59.1% recovery). Such a difference was shown to be reproducible over several months in 40 subjects who spanned the entire range of capacities. Cumulative plots and maximum likelihood analysis of the distribution indicated that a bimodal model was most probable. Analysis of pedigree data obtained from 12 families suggested a genetic effect with overlying environmental influences.
DOI: 10.1111/j.1365-2125.1984.tb02498.x
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