Article date: October 1984
By: G Sjolin‐Forsberg, J Hermansson, in Volume 18, Issue 4, pages 529-533
The relative bioavailability of lymecycline and tetracycline hydrochloride was compared in 12 healthy volunteers in a double‐blind cross‐over study using a high performance liquid chromatographic method for plasma and urine analyses. A statistical significant difference in favour of tetracycline hydrochloride was found concerning the mean AUC and the mean lag time. The relative bioavailability of lymecycline was only 70% compared with tetracycline in multiple dosing (19.13 +/‐ 5.39 micrograms ml‐1 h and 27.22 +/‐ 6.26 micrograms ml‐1 h respectively) and 80% in a single dose (21.88 +/‐ 4.23 micrograms ml‐1 h and 26.91 +/‐ 6.01 respectively) and the mean lag time of tetracycline was only 60% compared with lymecycline.
DOI: 10.1111/j.1365-2125.1984.tb02500.x
View this article