Stereoselective binding of propranolol enantiomers to human alpha 1‐ acid glycoprotein and human plasma.

The binding of propranolol enantiomers to human albumin (ALB), alpha 1‐ acid glycoprotein (alpha 1‐AGP) and plasma was studied. (‐) propranolol is more bound than (+)propranolol to alpha 1‐AGP (P less than 0.001) and to plasma (P less than 0.05). In solutions containing ALB at a constant concentration (580 mumol/l) and alpha 1‐AGP at increasing concentrations, the binding of both isomers increases but the stereo selectivity is evident throughout the alpha 1‐AGP concentration range examined (25‐100 mumol/l).

DOI: 10.1111/j.1365-2125.1984.tb02462.x

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