Article date: April 1983
By: O Delbruck, C Nagel, A Lichterfeld, in Volume 16, Issue S2, pages 391S-395S
Efficacy of and tolerance to brotizolam were studied over 6 days in elderly patients (62 to 93 years) suffering from sleep disturbance requiring medication: 62.9% used 0.125 mg and 32.0% used 0.25 mg. Effectiveness of brotizolam was assessed as good‐to‐satisfactory in 87.1% of the patients. Efficacy of and tolerance to brotizolam were compared with nitrazepam in mainly elderly patients (56‐91 years) with sleep disturbances requiring medication. Efficacy was assessed as good‐ to‐satisfactory in 89.8% of patients with 0.125 mg brotizolam, 93.9% with 0.25 mg brotizolam and 95.9% with 5 mg nitrazepam. Patients reported improved sleep with all three preparations. The dose range of brotizolam recommended for the elderly is 0.125‐0.25 mg, though for the vast majority of patients the lower dose will be sufficient.
DOI: 10.1111/j.1365-2125.1983.tb02315.x
View this article