Article date: April 1983
By: H Lohmann, O Delbruck, P Findeisen, in Volume 16, Issue S2, pages 403S-406S
Efficacy and tolerability of brotizolam (0.25 and 0.5 mg) were compared over a 6‐day period with nitrazepam (5.0 mg) in middle‐aged patients (less than 65 years) with sleep disturbances requiring medication. The study was double‐blind and randomised with a cross‐over design. Each preparation reduced sleep onset latency and frequency of awakenings, and improved quality and duration of sleep as well as subjective condition on awakening. Brotizolam 0.25 mg was found to be equally effective as 0.5 mg, and so the lower dose is recommended for the middle aged.
DOI: 10.1111/j.1365-2125.1983.tb02317.x
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