Article date: November 1983
By: J Staessen, A Cattaert, A Schaepdryver, R Fagard, P Lijnen, E Moerman, A Amery, in Volume 16, Issue 5, pages 553-556
The contribution of beta 1‐adrenoceptors to the regulation of plasma renin activity was investigated in nine healthy sodium‐replete volunteers: seven subjects received a cumulative intravenous dose of 75 micrograms/kg prenalterol, a predominant beta 1‐adrenoceptor agonist, and two subjects only vehiculum. In the seven actively treated subjects beta 1‐adrenoceptor agonism increased (P less than 0.001) systolic intra‐arterial pressure by an average of 16 +/‐ 4 mm Hg and heart rate by 19 +/‐ 3 beats min. These increases were significantly (P less than 0.04) different from the changes observed in the two control subjects (+ 3 +/‐ 4 mm Hg and ‐1 +/‐ 4 beats/min, respectively). Plasma renin activity, however, tended to decrease in both the actively (‐38%) and saline (‐28%) treated subjects. Predominant beta 1‐adrenoceptor agonism, powerful enough to increase systolic pressure and heart rate does not increase plasma renin activity in supine sodium‐replete normal man.
DOI: 10.1111/j.1365-2125.1983.tb02215.x
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