Article date: April 1983
By: A Heath, M Gabrielsson, CG Redgardh, in Volume 15, Issue 4, pages 490-492
The adsorption of beta‐adrenoceptor blockers and the partial beta‐ adrenoceptor agonist prenalterol was studied in an in vitro haemoperfusion (HP) model. Metoprolol, alprenolol, propranolol and prenalterol adsorb well from the blood to the resin with extraction ratios nearing 1.0. Extraction ratio for practolol was 0.68 and for atenolol 0.49. Protein binding has little effect on the degree of adsorption, which is more dependent on water solubility.
DOI: 10.1111/j.1365-2125.1983.tb01535.x
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