Article date: July 1982
By: JM Clifford, MD Day, JM Orwin, in Volume 14, Issue 1, pages 99-101
Clonidine given i.v. at a dose of 0.1 mg and 0.2 mg was found to cause miosis in a placebo controlled double‐blind study in six healthy volunteers. In a further single‐blind placebo controlled study in three of these volunteers, the alpha 2‐adrenoreceptor antagonist RX 781094 at a dose of 0.1 mg/kg i.v. reversed the miosis induced by i.v. clonidine 0.2 mg. At a dose of 0.05 mg/kg the miosis was partially reversed.
DOI: 10.1111/j.1365-2125.1982.tb04941.x
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