Article date: July 1982
By: PJ Morrison, HJ Rogers, RG Spector, ID Bradbrook, VA John, in Volume 14, Issue 1, pages 123-126
Pirprofen (a new non‐steroidal anti‐inflammatory agent), 200 mg 8 hourly, or placebo was administered orally to eight normal volunteers to investigate its effect on the pharmacokinetics and glucose and insulin responses after 1 mg i.v. glibenclamide. No significant changes were produced in these measures and in vitro studies showed no displacement of glibenclamide by pirprofen from plasma protein binding.
DOI: 10.1111/j.1365-2125.1982.tb04949.x
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